Explaining 'Unexplained Illnesses': Disease Paradigm for Chronic Fatigue Syndrome, Multiple Chemical Sensitivity, Fibromyalgia, Post-Traumatic Stress Disorder, and Gulf War Syndrome | 
 enlarge | Author: Martin L. Pall
Publisher: Informa Healthcare
Category: Book
List Price: $100.00
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Rating:  16 reviews
Sales Rank: 460049
Media: Paperback
Edition: 1
Pages: 446
Number Of Items: 1
Shipping Weight (lbs): 1.5
Dimensions (in): 8.4 x 6 x 1
ISBN: 078902389X
Dewey Decimal Number: 616.0478
EAN: 9780789023896
ASIN: 078902389X
Publication Date: April 23, 2007
Availability: Usually ships in 1 to 3 weeks
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Product Description
Discover the answer to the mysteries of these debilitating illnesses
Explaining “Unexplained Illnesses” provides long-sought explanations for the properties of chronic fatigue syndrome (CFS), multiple chemical sensitivity (MCS), fibromyalgia, and posttraumatic stress disorder. This groundbreaking book examines common symptoms and signs; short-term stressors such as infection, chemical exposure, physical trauma, and severe psychological stress; why people are often diagnosed as having more than one of these illnesses, and approaches for treating the cause of each disease, rather than the symptoms. The book presents a detailed and well-supported mechanism (the NO/ONOO- cycle) that provides consistent explanations for many of the puzzling elements of these diseases.
At least a dozen scientists have proposed that chronic fatigue syndrome, multiple chemical sensitivity, and fibromyalgia must share a common mechanism; others have suggested posttraumatic stress disorder may belong to this group as well. This unique book provides explanations for their previously unexplained properties with more than 1,500 references to scientific literature, creating a whole new approach to therapy and treatment of these illnesses.
Explaining "Unexplained Illnesses" provides answers to these questions:
- how do short-term stressors initiate chronic illness?
- how does the biochemistry of the NO/ONOO- cycle produce chronic illness?
- how can the diverse symptoms and signs of these illnesses be generated as a consequence of their common biochemistry?
- why is there so much variation in symptoms from one sufferer to another?
- what are the principles underlying the NO/ONOO- cycle mechanism?
- how does the NO/ONOO- cycle provide explanations for a dozen previously unexplained properties of these illnesses?
- how might 14 additional illnesses/diseases also be caused by the NO/ONOO- cycle etiology?
- and many more
Explaining “Unexplained Illnesses” is a must-read for physicians and scientists, and for anyone who suffers from-or knows someone who suffers from—these previously puzzling illnesses.
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Showing reviews 1-5 of 16
 Groundbreaking New Disease Paradigm September 7, 2007
Southern Reader (South Florida, USA)
29 out of 31 found this review helpful
In the groundbreaking new book "Explaining 'Unexplained Illnesses'", Dr. Martin Pall has proposed a new paradigm of human disease, the NO/ONOO- vicious cycle, which now explains CFS, MCS, FM, PTSD and GWS, bringing new hope for successful treatment and eventually a long hoped for cure. This paradigm also encompasses important illnesses such as asthma, autism, multiple sclerosis, Alzheimer's disease, Parkinson's disease and ALS, offering explanation and direction for research and treatment.
Dr. Pall clearly explains his new paradigm and the deranged biochemistry behind it. While the mechanism is complex, he gives hope to the millions who are suffering from these illnesses with an excellent chapter (Chapter 15) on treatment, mainly citing natural supplements as opposed to pharmaceuticals for disrupting this vicious cycle and returning the biochemistry to normal. He further explains the need for more research to develop the best treatment protocol and eventual cure.
Chapter 13, titled "What About Those Who Say It Is All in Your Head or That It All Starts in Your Head?", is a well-researched, heavily documented, pointed response to those who accuse these patients (of CFS and MCS particularly) of suffering from psychological/mental illness (or of being malingerers) rather than a physiological disease. As Dr. Pall points out, the chemical industry and insurance industry have vested interest in this issue, so as to avoid devastating liability lawsuits, payouts for disability, medical care and treatment.
As a former health care professional, I highly recommend this book as required reading for all people engaged in any aspect of the health care industry and all health care providers (from physicians to nurses to dentists) as well as for anyone who suffers from any of the illnesses impacted by this new disease paradigm. This book's importance cannot be overstressed.
Protocols for Treating Multiple Chemical Sensitivity, Fibromyalgia, Chronic Fatigue Syndrome, etc. Explained September 2, 2007
Elaine Tomko (Wilkes Barre, PA)
22 out of 23 found this review helpful
I hope you will make the time to read Dr. Pall's book and find it as inspirational and educational as I did. I was very excited to read about this NO/ONOO theory and explanation underlying these inflammatory illnesses: Multiple Chemical Sensitivity (MCS), Fibromyalgia (FM), Chronic Fatigue Syndrome (CFS), Gulf War Syndrome (GWS), Post Traumatic Stress Disorder (PTSD), etc. Take this book to your treating physician and discuss the protocols which fit your medical needs.
This book is dense with information - read the first chapter - The NO/ONOO Cycle and the Cause of Chronic Fatigue Syndrome, Multiple Chemical Sensitivity, Fibromyalgia and Post-Traumatic Stress Disorder. If you find it too technical, skip to the section about your illness, then go back and see if the chemistry is easier to understand. But everyone should read this book - even if they don't understand the chemistry - just for the supportive information which validates their experience with their illness.
Referring to MCS, Dr. Pall writes," MCS initiation commonly involves chemical exposure, either a single high-level exposure or multiple lower-level exposures. The chemicals involved in initiation of MCS fall mainly into four classes, organophosphorus and carbamate pesticides and two other classes of pesticides, and volatile organic solvents." Page 4
The chapter on therapies is most helpful as it provides detailed information on agents expected to down-regulate the vicious NO/ONOO cycle. "At least 30 therapeutic agents or classes of agents are available today that are expected to down-regulate cycle biochemistry." Page 265 Dr. Pall lists the various protocols of Drs. Paul Cheney, Jacob Teitlebaum, Garth Nicolson, Nash Petrovic, and Grace Ziem. He explains how each therapy and protocol acts to lower the NO/ONOO cycle or lowers NMDA activity, or acts as a nitric oxide scavenger or vanilloid antagonist.
These two statements stood out in the Chapter on MCS: "I estimated based on both, anecdotal reports and controlled exposure study, that MCS sufferers are at least 100 times more sensitive than normals and are probably more on the order of 1000 times more sensitive." 2 Page 114
And,"In one of my papers, I estimated that the prevalence of MCS from epidemiological studies is similar to that of diabetes, but the funding available for its study has been only about 1/1000th as much." 2 Page 113
Footnote 2. Pall ML. NMDA sensitization and stimulation by peroxynitrite, nitric oxide and organic solvents as the mechanism of chemical sensitivity in multiple chemical sensitivity, FASEB J 2002; 16:1407-1417
In the Therapy chapter discussing Dr. Grace Ziem's protocols, Dr. Pall writes: "Patients are advised to use environmental controls to reduce exposure to volatile organic solvents, pesticides and other irritant chemicals wherever possible. The therapeutic agents are not a substitute for avoidance of irritant chemicals, but rather are only effective in these chemically injured patients when used along with environmental controls." Page 312
My message to everyone suffering and disabled from the affects of MCS, FM, CFS, PTSD and other inflammatory illnesses is never give up hope - there is some treatment or protocol which will help you and your physician manage your illness.
Reading Dr. Pall's book has, personally, given me great hope for the future - for more successful treatments for MCS tailored to individual needs. We are hopeful that the protocols developed with this NO/ONOO theory in mind will be of great benefit to the health and healing of people with MCS and other inflammatory illnesses.
A novel idea, with ground-breaking potential. July 25, 2007
Kimberly A. Russo (Moscow, ID USA)
24 out of 26 found this review helpful
Dr. Martin Pall's book, Explaining "Unexplained Illnesses," proposes an insightful and carefully constructed theory for the cause of such mysterious illnesses as Chronic Fatigue Syndrome, Multiple Chemical Sensitivity, Fibromyalgia, Post-Traumatic Stress Disorder, and Gulf War Syndrome. It is a must-read for those in the health care profession as well as any individual who has, or knows someone who has, the afore mentioned illnesses.
The theory is somewhat complicated as it proposes an entirely new paradigm for disease, yet Dr. Pall presents the material in such a way that even an undergraduate like myself can understand it. Each chapter includes an introduction to help ease the reader into the topic, as well as take-home lessons to summaries the material in a digestible way. For those interested in going into greater detail on any of the particular diseases, there is an entire chapter devoted to each one. The book provides concise summaries as well as unabridged, through explanation. Basically, there is something for every type of reader.
Helpful Model for Unexplained Illness December 31, 2007
A Mackie (Ontario, Canada)
10 out of 11 found this review helpful
Dr. Pall's research and recommended treatment saved me. The core of my treatment for a variety of neurological and digestive problems involves his recommended techniques for down-regulating the NO/ONOO cycle. My improvement relies on specific supplements to turn down reactivity combined with avoidance of chemical and food irritants. I only dared read this book once I had recovered sufficiently to have hope again. Within its pages I found helpful advice, well-supported scientific explanations for my "weird" symptoms and some sobering observations. The lack of recognition of chemical toxicity leads to incredible suffering and financial hardship. Dr. Pall's book should be compulsory reading for every doctor. The biochemical mechanisms he describes should be researched thoroughly so that there can be proven treatments for the growing number of people with "unexplained illness". Also there needs to be increased awareness and regulation of those "harmless" chemicals that are literally destroying lives.
A lay person's perspection about the book. September 12, 2007
V. Rodriguez (Chicago, Illinois United States)
14 out of 18 found this review helpful
I found this book to be extremely insightful. It details very specifically some causes, stressors, effects, and cycles for each of the unexplained illnesses it references. This book is a definite "must have" for anyone wanting scientific reference. I am going to recommend this book to known health care providers, as well as, people who are experience these illnesses.
Showing reviews 1-5 of 16
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